The microscope was already available
Anton van Leeuwenhoek made careful observations of microscopic organisms, which he called animalcules.
Anton van Leeuwenhoek died
He performed numerous experiments to discover why wine and dairy products became sour, and he found that bacteria were to blame. began to wonder if bacteria could cause disease in humans
Develop the germ theory of disease. It was a year called: Golden Age of Microbiology during which many agents of different infectious diseases were identified.
the electron microscope was developed and perfected
With the development of vaccines, such viral diseases as polio, measles, mumps, and rubella came under control.
development of pharmaceutical products, the use of quality‐control methods in food and dairy product production, microorganisms are used to produce vitamins and applied the biotechnology.