PDB carnitine acyltransferases family

ARTICLE| VOLUME 112, ISSUE 1, P113-122, JANUARY 10, 2003
Crystal Structure of Carnitine Acetyltransferase and Implications for the Catalytic Mechanism and Fatty Acid Transport
Gerwald Jogl, Liang Tong

https://www.cell.com/cell/fulltext/S0092-8674(02)01228-X?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS009286740201228X%3Fshowall%3Dtrue

Structure of Human Carnitine Acetyltransferase
MOLECULAR BASIS FOR FATTY ACYL TRANSFER

Donghai Wu‡, Lakshmanan Govindasamy§, Wei Lian‡, Yunrong Gu‡, Thomas Kukar‡, Mavis Agbandje-McKenna§ and Robert McKenna§¶

doi: 10.1074/jbc.M212356200

Crystal Structure of Mouse Carnitine Octanoyltransferase
DOI: 10.2210/pdb1XL7/pdb
https://www.rcsb.org/structure/1XL7
Classification: TRANSFERASE
Organism(s): Mus musculus
Expression System: Escherichia coli
Mutation(s): Yes

Deposited: 2004-09-30 Released: 2004-10-19
Deposition Author(s): Jogl, G., Hsiao, Y.S., Tong, L.
Experimental Data Snapshot

Method: X-RAY DIFFRACTION
Resolution: 2.00 Å
R-Value Free: 0.217
R-Value Work: 0.190
R-Value Observed: 0.190

Crystal structure of mouse carnitine octanoyltransferase and molecular determinants of substrate selectivity.
Jogl, G., Hsiao, Y.S., Tong, L.
(2005) J Biol Chem 280: 738-744

PubMed: 15492013 Search on PubMed
DOI: 10.1074/jbc.M409894200

Crystal structure of mouse carnitine octanoyltransferase in complex with octanoylcarnitine
DOI: 10.2210/pdb1XL8/pdb
https://www.rcsb.org/structure/1XL8
Classification: TRANSFERASE
Organism(s): Mus musculus
Expression System: Escherichia coli
Mutation(s): Yes

Deposited: 2004-09-30 Released: 2004-10-19
Deposition Author(s): Jogl, G., Hsiao, Y.S., Tong, L.
Experimental Data Snapshot

Method: X-RAY DIFFRACTION
Resolution: 2.20 Å
R-Value Free: 0.230
R-Value Work: 0.199
R-Value Observed: 0.199

Crystal structure of mouse carnitine octanoyltransferase and molecular determinants of substrate selectivity.
Jogl, G., Hsiao, Y.S., Tong, L.
(2005) J Biol Chem 280: 738-744

PubMed: 15492013 Search on PubMed
DOI: 10.1074/jbc.M409894200

C323M mutant structure of mouse carnitine octanoyltransferase
DOI: 10.2210/pdb1XMC/pdb
https://www.rcsb.org/structure/1XMC
Classification: TRANSFERASE
Organism(s): Mus musculus
Expression System: Escherichia coli
Mutation(s): Yes

Deposited: 2004-10-01 Released: 2004-10-19
Deposition Author(s): Jogl, G., Hsiao, Y.S., Tong, L.
Experimental Data Snapshot

Method: X-RAY DIFFRACTION
Resolution: 2.00 Å
R-Value Free: 0.217
R-Value Work: 0.190

Crystal structure of mouse carnitine octanoyltransferase and molecular determinants of substrate selectivity.
Jogl, G., Hsiao, Y.S., Tong, L.
(2005) J Biol Chem 280: 738-744

PubMed: 15492013 Search on PubMed
DOI: 10.1074/jbc.M409894200

M335V mutant structure of mouse carnitine octanoyltransferase
DOI: 10.2210/pdb1XMD/pdb
https://www.rcsb.org/structure/1XMD
Classification: TRANSFERASE
Organism(s): Mus musculus
Expression System: Escherichia coli
Mutation(s): Yes

Deposited: 2004-10-01 Released: 2004-10-19
Deposition Author(s): Jogl, G., Hsiao, Y.S., Tong, L.
Experimental Data Snapshot

Method: X-RAY DIFFRACTION
Resolution: 2.10 Å
R-Value Free: 0.224
R-Value Work: 0.196

Crystal structure of mouse carnitine octanoyltransferase and molecular determinants of substrate selectivity.
Jogl, G., Hsiao, Y.S., Tong, L.
(2005) J Biol Chem 280: 738-744

PubMed: 15492013 Search on PubMed
DOI: 10.1074/jbc.M409894200

https://www.jbc.org/content/280/1/738

Crystal structure of rat carnitine palmitoyltransferase II
DOI: 10.2210/pdb2H4T/pdb
Classification: TRANSFERASE
Organism(s): Rattus norvegicus
Expression System: Escherichia coli
Mutation(s): Yes

Deposited: 2006-05-25 Released: 2006-07-25
Deposition Author(s): Hsiao, Y.S., Jogl, G., Esser, V., Tong, L.
Experimental Data Snapshot

Method: X-RAY DIFFRACTION
Resolution: 1.90 Å
R-Value Free: 0.221
R-Value Work: 0.189
R-Value Observed: 0.189

https://www.rcsb.org/structure/2H4T

Crystal structure of rat carnitine palmitoyltransferase 2 in complex with antidiabetic drug ST1326
DOI: 10.2210/pdb2FW3/pdb
Classification: TRANSFERASE
Organism(s): Rattus norvegicus
Expression System: Escherichia coli BL21(DE3)

Deposited: 2006-02-01 Released: 2007-02-01
Deposition Author(s): Rufer, A.C., Thoma, R., Benz, J., Stihle, M., Gsell, B., De Roo, E., Banner, D.W., Mueller, F., Chomienne, O., Hennig, M.
http://www.rcsb.org/structure/2FW3

Crystal structure of rat carnitine palmitoyltransferase 2 in space group P43212
DOI: 10.2210/pdb2FYO/pdb
Classification: TRANSFERASE
Organism(s): Rattus norvegicus
Expression System: Escherichia coli

Deposited: 2006-02-08 Released: 2007-02-08
Deposition Author(s): Rufer, A.C., Thoma, R., Benz, J., Stihle, M., Gsell, B., De Roo, E., Banner, D.W., Mueller, F., Chomienne, O., Hennig, M.
http://www.rcsb.org/structure/2FYO

Crystal structure of rat carnitine palmitoyltransferase 2 in space group C2221
DOI: 10.2210/pdb2DEB/pdb
Classification: TRANSFERASE
Organism(s): Rattus norvegicus
Expression System: Escherichia coli BL21(DE3)

Deposited: 2006-02-10 Released: 2007-02-10
Deposition Author(s): Rufer, A.C., Thoma, R., Benz, J., Stihle, M., Gsell, B., De Roo, E., Banner, D.W., Mueller, F., Chomienne, O., Hennig, M.
http://www.rcsb.org/structure/2DEB

Crystal structure of rat carnitine palmitoyltransferase 2 in complex with r-3-(hexadecanoylamino)-4-(trimethylazaniumyl)butanoate
DOI: 10.2210/pdb2RCU/pdb
Classification: TRANSFERASE
Organism(s): Rattus norvegicus
Expression System: Escherichia coli BL21(DE3)

Deposited: 2007-09-20 Released: 2007-10-16
Deposition Author(s): Rufer, A.C., Benz, J., Chomienne, O., Thoma, R., Hennig, M.
https://www.rcsb.org/structure/2RCU

4EP9
CRYSTAL STRUCTURE OF RAT CARNITINE PALMITOYLTRANSFERASE 2 IN COMPLEX WITH CoA-site inhibitor
DOI: 10.2210/pdb4EP9/pdb
Classification: TRANSFERASE/TRANSFERASE INHIBITOR
Organism(s): Rattus norvegicus
Expression System: Escherichia coli BL21(DE3)

Deposited: 2012-04-17 Released: 2013-04-17
Deposition Author(s): Rufer, A.C., Thoma, R., Benz, J., Stihle, M., Gsell, B., De Roo, E., Banner, D.W., Mueller, F., Chomienne, O., Hennig, M.
http://www.rcsb.org/structure/4EP9

4EPH
CRYSTAL STRUCTURE OF RAT CARNITINE PALMITOYLTRANSFERASE 2 IN COMPLEX with CoA-site inhibitor
DOI: 10.2210/pdb4EPH/pdb
Classification: TRANSFERASE/TRANSFERASE INHIBITOR
Organism(s): Rattus norvegicus
Expression System: Escherichia coli BL21(DE3)

Deposited: 2012-04-17 Released: 2013-04-17
Deposition Author(s): Rufer, A.C., Thoma, R., Benz, J., Stihle, M., Gsell, B., De Roo, E., Banner, D.W., Mueller, F., Chomienne, O., Hennig, M.

4EYW
Crystal structure of rat carnitine palmitoyltransferase 2 in complex with 1-[(R)-2-(3,4-Dihydro-1H-isoquinoline-2-carbonyl)-piperidin-1-yl]-2-phenoxy-ethanone
DOI: 10.2210/pdb4EYW/pdb
Classification: Transferase/Transferase Inhibitor
Organism(s): Rattus norvegicus
Expression System: Escherichia coli BL21(DE3)

Deposited: 2012-05-02 Released: 2013-04-24
Deposition Author(s): Rudolph, M.G., Benz, J., Burger, D., Thoma, R., Rufer, A., Joseph, C.
http://www.rcsb.org/structure/4EYW

The Crystal Structure of Carnitine
Palmitoyltransferase 2 and Implications
for Diabetes Treatment

A Monotopic Membrane Protein Goes Solo

Crystal structure of rat carnitine palmitoyltransferase II (CPT-II)

Carnitine palmitoyltransferase 2: Analysis of membrane association
and complex structure with a substrate analog

Isothermal titration calorimetry with micelles: Thermodynamics of inhibitor binding to carnitine palmitoyltransferase 2 membrane protein

2LE3
N-terminal regulatory segment of carnitine palmitoyltransferase 1A
DOI: 10.2210/pdb2LE3/pdbBMRB: 17690
Classification: TRANSFERASE
Organism(s): Homo sapiens
Expression System: Escherichia coli

Deposited: 2011-06-06 Released: 2011-10-19
Deposition Author(s): Ulmer, T.S., Rao, J.N.
Experimental Data Snapshot

Method: SOLUTION NMR
Conformers Calculated: 20
Conformers Submitted: 20
Selection Criteria: structures with the lowest energy

http://www.rcsb.org/structure/2LE3

An Environment-dependent Structural Switch Underlies the Regulation of Carnitine Palmitoyltransferase 1A.
Rao, J.N., Warren, G.Z., Estolt-Povedano, S., Zammit, V.A., Ulmer, T.S.
(2011) J Biol Chem 286: 42545-42554

PubMed: 21990363 Search on PubMedSearch on PubMed Central
DOI: 10.1074/jbc.M111.306951

Structure of the Regulatory Domain of Human Brain Carnitine Palmitoyltransferase 1
DOI: 10.2210/pdb2M76/pdbBMRB: 19174
Classification: SIGNALING PROTEIN
Organism(s): Homo sapiens
Expression System: Escherichia coli

http://www.rcsb.org/structure/2M76

Deposited: 2013-04-18 Released: 2013-09-11
Deposition Author(s): Samanta, S., Situ, A.J., Ulmer, T.S.

Structural characterization of the regulatory domain of brain carnitine palmitoyltransferase 1.
Samanta, S., Situ, A.J., Ulmer, T.S.
(2014) Biopolymers 101: 398-405

PubMed: 24037959
DOI: 10.1002/bip.22396

Crystal structure of rat choline acetyltransferase
DOI: 10.2210/pdb1Q6X/pdb
Classification: TRANSFERASE
Organism(s): Rattus norvegicus
Expression System: Escherichia coli

Deposited: 2003-08-14 Released: 2004-06-01
Deposition Author(s): Cai, Y., Rodgers, D.W.
https://www.rcsb.org/structure/1Q6X

Structural Insights and Functional Implications of Choline Acetyltransferase
DOI: 10.2210/pdb1T1U/pdb
Classification: TRANSFERASE
Organism(s): Rattus norvegicus
Expression System: Escherichia coli

Deposited: 2004-04-18 Released: 2005-04-12
Deposition Author(s): Govindasamy, L., Pedersen, B., Lian, W., Kukar, T., Gu, Y., Jin, S., Agbandje-McKenna, M., Wu, D.
https://www.rcsb.org/structure/1T1U

Structures of ligand bound human choline acetyltransferase provide insight into regulation of acetylcholine synthesis
DOI: 10.2210/pdb2FY2/pdb
Classification: TRANSFERASE
Organism(s): Homo sapiens
Expression System: Escherichia coli BL21(DE3)
Mutation(s): 7
Deposited: 2006-02-07 Released: 2006-12-12
Deposition Author(s): Kim, A.R., Rylett, R.J., Shilton, B.H.

Experimental Data Snapshot:
Method: X-RAY DIFFRACTION
Resolution: 2.25 Å
R-Value Free: 0.234
R-Value Work: 0.195
R-Value Observed: 0.208

https://www.rcsb.org/structure/2FY2

Structures of ligand bound human choline acetyltransferase provides insight into regulation of acetylcholine synthesis
DOI: 10.2210/pdb2FY3/pdb
Classification: TRANSFERASE
Organism(s): Homo sapiens
Expression System: Escherichia coli BL21(DE3)
Mutation(s): 7
Deposited: 2006-02-07 Released: 2006-12-12
Deposition Author(s): Kim, A.R., Rylett, R.J., Shilton, B.H.
https://www.rcsb.org/structure/2FY3

Structures of ligand bound human choline acetyltransferase provide insight into regulation of acetylcholine synthesis
DOI: 10.2210/pdb2FY4/pdb
Classification: TRANSFERASE
Organism(s): Homo sapiens
Expression System: Escherichia coli BL21(DE3)
Mutation(s): 7
Deposited: 2006-02-07 Released: 2006-12-12
Deposition Author(s): Kim, A.R., Rylett, R.J., Shilton, B.H.

Structures of ligand bound human choline acetyltransferase provide insight into regulation of acetylcholine synthesis
DOI: 10.2210/pdb2FY5/pdb
Classification: TRANSFERASE
Organism(s): Homo sapiens
Expression System: Escherichia coli BL21(DE3)
Mutation(s): 7
Deposited: 2006-02-07 Released: 2006-12-12
Deposition Author(s): Kim, A.R., Rylett, R.J., Shilton, B.H.

https://www.embopress.org/doi/10.1038/sj.emboj.7600221

Substrate Binding and Catalytic Mechanism of Human Choline Acetyltransferase†,‡
Ae-Ri KimR. Jane RylettBrian H. Shilton

https://pubs.acs.org/doi/10.1021/bi061536l

GERWALD JOGL, YU-SHAN HSIAO, AND LIANG TONG

Structure and Function of Carnitine Acyltransferases