Serena wins the U.S. Open at age 17, becoming the first of the Williams sisters to claim a Grand Slam singles title.
Approx. September 1999
Williams pulls off the "Serena Slam," claiming four straight Grand Slam titles -- the French Open, Wimbledon and U.S. Open in 2002 and the Australian Open in 2003.
June 2002 - January 2003
she had season-ending knee surgery, and her older half-sister, Yetunde Price, was murdered in September.
Approx. July 2003
Serena beats Venus in the Wimbledon final to claim her sixth career major title in what would be her final tournament of the year.
Approx. July 2003
Serena loses to 17-year-old Maria Sharapova in the Wimbledon final.
Approx. July 2004
Serena slices a tendon in her foot by stepping on broken glass as she leaves a Munich restaurant. The injury requires surgeries in July and October 2010.
Approx. July 7, 2010
Serena requires emergency treatment for a hematoma in her stomach that likely developed as a result of her use of blood thinners.
Approx. February 28 2011
Serena bows out in the fourth round of Wimbledon, falling in two tough sets to Marion Bartoli. Williams has not lost a match since.