Serena wins the U.S. Open at age 17, becoming the first of the Williams sisters to claim a Grand Slam singles title.
~September 1999
Williams pulls off the "Serena Slam," claiming four straight Grand Slam titles -- the French Open, Wimbledon and U.S. Open in 2002 and the Australian Open in 2003.
June 2002 - January 2003
she had season-ending knee surgery, and her older half-sister, Yetunde Price, was murdered in September.
~July 2003
Serena beats Venus in the Wimbledon final to claim her sixth career major title in what would be her final tournament of the year.
~July 2003
Serena loses to 17-year-old Maria Sharapova in the Wimbledon final.
~July 2004
Serena slices a tendon in her foot by stepping on broken glass as she leaves a Munich restaurant. The injury requires surgeries in July and October 2010.
~July 7, 2010
Serena requires emergency treatment for a hematoma in her stomach that likely developed as a result of her use of blood thinners.
~February 28 2011
Serena bows out in the fourth round of Wimbledon, falling in two tough sets to Marion Bartoli. Williams has not lost a match since.