430 B.C.- During the second year of the Peloponnesian War, Thucydides writes about a disease that is believed to have been the Plague
540 A.D.- An outbreak of Plague occurs at Pelusium, Egypt.
542 A.D.- Plague reaches Constantinople.
1334- Plague occurs in Constantinople
1339-1346- The famine occurs. This goes on for seven years and is known as "the famine before the plague."
1347- The Black Plague began spreading through Western Europe