in 1836, Marcus and Narcissa Whitman, missionaries, travel to Fort Vancouver from New York. They are accompanied by fellow missionaries Henry and Eliza Spalding, William Gray, two hired men, and three Nez Perces. They make it by cart as far as Fort Boise, the farthest west a wheeled cart had yet made it. The Whitmans established their homestead in Cayuse territory at Waiilatpu, which became a permanent fixture for future settlers.
Cultural misunderstandings led to the tragic Whitman massacre in 1847, when members of the Cayuse Tribe killed Marcus and Narcissa and 11 others. Many missionaries left the area after this, ending an era in the history of Protestant missionaries. (Schwantes,84-88)