More than 60 Indian tribes live in Panama, connected with the Mayas of Guatemala and Mexico and the Chibchas of Colombia.
Rodrigo de Bastidas, sailing westward from Venezuela, arrives in search of gold.
Christopher Columbus establishes a short-lived settlement on the Isthmus.
The Spanish establish Santa Maria la Antigua del Darien, the first mainland settlement in the Americas.
Panama declares independence from spain.
A French company led by Ferdinand de Lesseps attempts unsccessfully to construct a sea-level canal on the site of the present Panama Canal.
Panama proclaims its independence from columbia and concludes the Hay/Bunau-Varilla treaty with the United States.
United States completes the existing 50-miles(83 km) Panama Canal.
Anti-United States riots over control of the Canal result in the deaths of four U.S. Marines and more than twenty Panamanians.
Ernesto Perez Balladares wins the presidency in panama's largest election