The Missouri Compromise led to the Civil War because it caused the North Louisiana Territory into free and slave states. It made the slave free northern states seem more aggressive with their beliefs on slavery. This contributed to the resentment towards the south. This raised the stakes for war because the compromise increased the political and sectional rivalries between the north and south. While the people of the North believe that slavery is wrong the Southerners believe that slavery is okay. At this time the United States had 22 states. So when the South seceded from the Union the split was equal between both sides.