Leonardo Da Vinci was born near the town of Vinci
At 15 Leonardo is sent to Florence to work as apprentice to Andrea De Verrocchio.
20 year-old Leonardo is accepted into the painters' guild of Florence.
Leonardo is accused of sodomy; he is publicly humiliated although the charges are later dropped.
The Annunciation is painted. The work, initially credited to Da Vinci, is now believed to have been painted by Lorenzo di Credi.
Leonardo begins work on The Adoration of the Magi, an altarpiece for the Monastery of San Donato at Scopeto.He sketches many studies.
Leonardo moves to Milan to work in the service of the city's duke, Ludovico Sforza. He gains the title of "painter and engineer of the duke.
Leonardo paints the Virgin of the Rocks.
Leonardo paints Lady with an Ermine.
Leonardo begins work on The Last Supper in the refectory of the convent of Santa Maria delle Grazie in Milan.
The Last Supper is completed.
With the duke Ludovico Sforza'a fall from power, Da Vinci leaves Milan and spends a short time in Venice.
Leonardo begins painting the Virgin and Child with Saint Anne, a project that he only finishes after 10 years and Leo returns to Florence.
Leonardo begins work as senior military architect and general engineer for Cesare Borgia, son of Pope Alexander VI.
Leonardo is commission to paint a mural for the council hall in Florence's Palazzo Vecchio, which is to be the Battle of Anghiari, a work that would remain unfinished.
Leonardo is commissioned to paint the Mona Lisa.
Leonardo paints St. John the Baptist.
The king of France invites Leonardo to come work for him.
May 2, Leonardo dies in France.