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Events

HGS founding

Approx. June 1, 1992

First report of BLyS gene HNEDU15 in HGS patent

May 1, 1998

BLyS puplication

July 1, 1999

Anti-BLyS Ab development

October 1, 2000

SLE phase I trials

November 1, 2001

SLE phase I results

April 1, 2003

SLE phase II trials

September 1, 2003

RA phase 2 trials

January 1, 2004

RA phase II results

April 1, 2005

GSK exercises option

July 1, 2005

SLE phase II results

October 1, 2005

FDA gave SPA for BLISS

October 1, 2006

BLISS-52

February 1, 2007

BLISS-76

May 1, 2007

Data announcement of positive BLISS-52

July 1, 2009

Data announcement of positive BLISS-76

November 1, 2009

Submit BLA to FDA

June 1, 2010

Advisory committee by FDA

November 16, 2010

FDA approval

March 9, 2011