The Hundred Years War was a war between England and France over feudal disputes that lasted 116 years, with fighting divided over the course of that time.
A plague from rats imported from ships from Asia that caused the death of 1/3 of Europe.
Period of relative peace and intellect throughout Italy that lead to a great deal of art and culture, ending with the sacking of Rome.
Until 1450, the Italian Renaissance had little effect on Northern Europe. However, ideas began to spread, leading to a renaissance period in Northern Europe and ending after the Thirty Years' War.