History of SLE

Events

Cazenave described the discoid lupus of SLE as “erythema centrifungum”

1833

Classical Period

1833 - 1872

SLE described as a cutaneous disorder

Dr. Ferdinand von Hebra (Vienna) identified the butterfly (malar) rash

1846

Dr. Ferdinand von Hebra published illustrations of the malar rash then-termed “lupus erythematosus” in the Atlas of Skin Diseases

1856

Neoclassical Period

1872 - 1948

Moriz Kaposi recognized SLE as a systemic disease with visceral manifestations. Kaposi described two forms of the disease: discoid form and disseminated form

1872

Osler in Baltimore and Jadassohn in Vienna supported SLE being a systemic illness

1904

Reinhart and Hauck (Germany) identifying false positive syphilis tests in SLE patients

1909

Libman and Sacks (New York) acknowledge and study SLE endocarditis lesions

1923

Baehr describes SLE glomerular changes

1935

Klemperer, Pollack, and Baehr describe SLE as “diffuse connective tissue disease” in which they specifically termed it “collagen vascular disease”

1941

Modern Period

1948 - 2015

Hargraves, Richmond, and Morton discover the LE cells at the Mayo Clinic

1948

Friou used indirect immunofluorescence to see the presence of antinuclear antibodies in the blood of SLE patients

1948

Discovery of DNA antibodies, antibodies to extractable nuclear antigens (nuclear ribonucleoprotein [nRNP], Sm, Ro, La)

1948

Leonhardt noted familial occurrence of systemic lupus, which was later studied by Arnett and Shulman at John Hopkins

1954