Biomarkers Projected Accrual Timeline

Feb 2011 - Oct 2011

49 Samples Collected

02/01/2011 - 10/11/2011

Oct 2011-Oct 2012

96 + 49 = 145 Samples Collected

02/01/2011 - 10/31/2012

Oct 2012 - Oct 2013

96 + 96 + 49 = 241 Samples Collected

02/01/2011 - 10/31/2013

Milestones

49 Samples + 233 Plasma Samples Collected

10/11/2011

Interim Plasma Analysis, 300 Plasma Samples Collected (Feb 2011)

02/15/2012

Interim Cell Analysis (Oct 2012)

10/31/2012

Final Analysis (Oct 2013)

10/31/2013